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Hexamethyldisilazane (HMDS) CAS 999-97-3
Overview
Hexamethyldisilazane (HMDS) is a clear, colorless, and highly volatile organosilicon liquid with a distinct ammonia-like odor. Celebrated for its mild yet highly effective reactivity, HMDS is universally recognized as the premier silylating agent in complex organic synthesis and the ultimate adhesion promoter in semiconductor wafer fabrication. Unlike traditional chlorosilanes, HMDS releases only benign ammonia gas during reactions, completely eliminating the risk of hydrochloric acid-induced degradation in sensitive molecular structures.
Product Description
Hexamethyldisilazane (HMDS) is a clear, colorless, and highly volatile organosilicon liquid. Celebrated for its mild yet highly effective reactivity, HMDS is universally recognized as the premier silylating agent in complex organic synthesis and the ultimate adhesion promoter in semiconductor wafer fabrication. Unlike traditional chlorosilanes, HMDS releases only benign ammonia gas during reactions, completely eliminating the risk of acid-induced degradation in sensitive molecular structures.
At Shandong Yinglang Chemical Co., Ltd., established in 2016, we supply bulk volumes of Ultra-High Purity HMDS to the world's leading API manufacturers and semiconductor fabs. Operating strictly under Class 3 Dangerous Goods protocols, our HMDS is packaged under an absolute dry, Nitrogen-blanketed environment, guaranteeing zero hydrolytic degradation and flawless precision in your high-tech applications.
For semiconductor photolithography and advanced API synthesis, trace metals and moisture must be strictly eliminated. Typical specifications for our Electronic Grade:
| Purity (HMDS) | ≥ 99.9% |
|---|---|
| Hexamethyldisiloxane (HMDSO) | ≤ 0.05% |
| Moisture / Water | ≤ 0.01% |
| Trace Metals (Fe, Cu, Pb) | ≤ 10 ppb |
| Color (Pt-Co) | ≤ 10 |
- Semiconductor Photolithography: The industry-standard adhesion promoter. Vapor-deposited onto silicon wafers to ensure flawless adhesion of photoresists prior to UV exposure and etching.
- Pharmaceutical Synthesis: Extensively used as a mild protecting group reagent during the synthesis of advanced antibiotics (Penicillin, Cephalosporins) and synthetic steroids.
- Fumed Silica Treatment: Utilized to hydrophobize the surface of fumed silica for premium silicone rubbers and adhesives.
- Chromatography: Used to deactivate glass surfaces in GC columns, preventing the adsorption of polar compounds.
For pharmaceutical CROs synthesizing highly sensitive APIs, utilizing traditional Trimethylchlorosilane (TMCS) can be disastrous, as it releases destructive hydrochloric acid (HCl) during the silylation process. HMDS acts as a far superior donor of trimethylsilyl groups because its only byproduct is ammonia (NH3) gas, which easily bubbles out of the reaction matrix. This ensures your sensitive molecular backbones remain intact, drastically improving batch yields.
Because HMDS is highly flammable and hydrolyzes instantly upon contact with moisture, our packaging ensures absolute safety during ocean transit:
- ISO TANKS (18 - 20 MT) (Highly recommended for massive semiconductor chemical distributors, completely N2-purged).
- 150 KG / 160 KG Heavy-duty UN-approved Steel Drums, tightly sealed and strictly Nitrogen-blanketed.
- Transport Classification: Classified as Class 3 (Flammable Liquid) with Subsidiary Risk 8 (Corrosive).
- UN Number: UN 2924 | Packing Group: II
- Handling Precautions: HIGHLY FLAMMABLE. Causes severe skin burns. Reacts with moisture to release toxic ammonia. Operators MUST handle inside a completely dry, explosion-proof environment wearing full hazmat gear.
Contact us today for the latest FOB/CIF pricing, detailed COA, and specialized DG shipping estimates for your pharmaceutical or semiconductor facility.
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PACKING AND DELIVERY
Packing and delivery
We offer secure and compliant packaging for a wide range of chemical products, from laboratory bottles (100 mL, 250 mL, 500 mL) to customized bulk containers. All shipments follow international hazardous goods standards and include complete documentation such as COA and SDS. With reliable global logistics partners, we ensure safe, fast, and efficient delivery by air, sea, or land according to customer needs.
FAQ
Q1: What documents and certifications do you provide?
A Standard shipment includes COA (Certificate of Analysis) and MSDS (SDS). We also provide ISO 9001 certification and support third-party inspections like SGS or BV upon request.
Q2: Do you provide custom synthesis or formulation services?
A Yes. If you have specific purity requirements or a unique formulation, our R&D team can provide custom synthesis and adjust the stabilizers/inhibitors to meet your technical specifications.
Q3: What are your terms of payment?
A
For Orders ≤ $1,000: 100% in advance.
For Orders > $1,000: 30% T/T in advance, and the balance before shipment or against the copy of B/L. Irrevocable L/C at sight is also acceptable for bulk orders.
Q4: How long is your price valid?
A Chemical prices fluctuate due to the changes in raw material costs and exchange rates. Please contact our sales team for the latest real-time quotation.
Q5: What packaging and shipping ports are available?
A
We normally ship from Qingdao, Shanghai, or Ningbo.
Standard packaging includes 200kg Drums or 1000kg IBC Totes. We ensure strict safety compliance for both general and hazardous chemical cargoes.
Q6: It's my first time importing chemicals — can you help?
A Absolutely. Importing chemicals requires specific documentation. Our experienced logistics team will assist you with the entire process, including handling customs clearance documents and arranging the most suitable shipping method.