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CAS 4111-54-0 Lithium diisopropylamide liquid
Overview
Lithium Diisopropylamide (LDA, i-Pr₂NLi, CAS 4111-54-0, C₆H₁₄LiN, 107.16 g/mol) is a strong, sterically hindered, non-nucleophilic base used for kinetic enolate formation, regioselective deprotonation of carbonyls/nitriles/sulfones/heteroarenes, directed lithiation, and E2 eliminations in pharmaceutical and fine-chemical synthesis.
Product Description
CAS 4111-54-0 Lithium diisopropylamide
Lithium diisopropylamide (LDA, i-Pr₂NLi) is a powerful, sterically hindered non-nucleophilic base widely used in pharmaceuticals, fine chemicals, and materials research. It enables kinetic enolate formation, regioselective deprotonation of carbonyls/nitriles/sulfones/heteroarenes, directed lithiation, and E2 eliminations, delivering fast, clean transformations with excellent control over site selectivity.
Lithium Diisopropylamide (LDA) — Product Specification
CAS: 4111-54-0 | Formula: C6H14LiN | Molecular weight: 107.16 g/mol | Synonyms: LDA; Lithium N,N-diisopropylamide; i-Pr2NLi
Identity & Form
| Product form | Solution in mixed solvents |
|---|---|
| Typical concentrations | 1.0–2.0 M (custom on request) |
| Solvent options | THF/hexanes · THF/heptane (other solvents on request) |
| Assay / Active base | Titration (reported on COA); concentration tolerance typically ±0.05–0.10 M |
| Residual amine (diisopropylamine) | ≤ 0.50% (w/w) typical |
| Water (Karl Fischer) | ≤ 0.20% (w/w) typical |
| Appearance | Colorless to pale yellow, clear solution; free from visible particulates |
| Stabilizers | None added |
| Documents | COA · TDS · SDS · DG documents |
Applications & Handling
| Main uses | Kinetic enolate formation; regioselective deprotonation of carbonyls/nitriles/sulfones/heteroarenes; directed lithiation; E2 eliminations |
|---|---|
| Recommended conditions | Strictly anhydrous, oxygen-free systems; commonly operated at −78–0 °C for selectivity and heat control |
| Safety | Air/moisture-sensitive; solvents are flammable. Handle under inert gas with dry apparatus; avoid water/alcohols/oxidants; follow SDS and validated quench procedures. |
Packaging & Logistics
| Lab packs | Septum-sealed glass bottles (e.g., 100 mL · 500 mL · 1 L) |
|---|---|
| Bulk | Inerted, sealed metal containers; flow-friendly concentrations available |
| Shipping | Dangerous Goods (flammable solvent; air/moisture sensitive); compliant packing & labeling |
| Ports | Qingdao · Shanghai · Tianjin |
| To quote (please specify) | Concentration (M), solvent system, pack size, destination country/port, and required documents |
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PACKING AND DELIVERY
Packing and delivery
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