Skip to content 
1,4-Dibromobutane | Advanced Pharmaceutical Intermediate | CAS 110-52-1
Overview
1,4-Dibromobutane is a clear, colorless to light yellow, high-density liquid. Characterized by possessing two highly reactive bromine atoms at opposite ends of a four-carbon aliphatic chain, it is a premier bifunctional alkylating agent. This unique molecular architecture makes it an incredibly powerful building block in advanced organic synthesis, specifically engineered for high-yield ring-closing (cyclization) reactions in pharmaceutical manufacturing and serving as the perfect “spacer” molecule in the synthesis of next-generation Gemini surfactants.
Product Description
1,4-Dibromobutane is a clear, high-density liquid. Characterized by possessing two highly reactive bromine atoms at opposite ends of a four-carbon aliphatic chain, it is a premier bifunctional alkylating agent. This unique molecular architecture makes it an incredibly powerful building block in advanced organic synthesis, specifically engineered for high-yield ring-closing (cyclization) reactions in pharmaceutical manufacturing and serving as the perfect "spacer" molecule in the synthesis of next-generation Gemini surfactants.
At Shandong Yinglang Chemical Co., Ltd., established in 2011, we supply bulk commercial volumes of Ultra-High Purity 1,4-Dibromobutane to multinational pharmaceutical CDMOs and specialty surfactant formulators. Handled strictly under Dangerous Goods protocols, our product is packaged in nitrogen-purged, light-blocking UN steel drums, guaranteeing absolute molecular stability and zero degradation during global transit.
For sensitive API synthesis and high-end surfactants, the strict elimination of free bromine and moisture is mandatory. Typical specifications:
| Purity (1,4-Dibromobutane) | ≥ 99.0% |
|---|---|
| Moisture / Water | ≤ 0.1% |
| Color (APHA) | ≤ 30 |
| Density (at 20°C) | 1.808 - 1.812 g/cm³ |
| Refractive Index | 1.517 - 1.520 |
- Pharmaceutical Synthesis (APIs): Utilized extensively as a cyclizing agent to synthesize pyrrolidine rings and complex heterocyclic compounds for anxiolytic drugs and cardiovascular therapeutics.
- Gemini Surfactants: Acts as the essential hydrophobic "spacer group" linking two polar surfactant heads, drastically improving biocidal efficiency in quaternary ammonium compounds.
- Agrochemicals: Utilized in the synthesis of high-efficiency, broad-spectrum crop protection chemicals.
- Organometallic Synthesis: Serves as a fundamental starting material for preparing bis-Grignard reagents.
When synthesizing heterocyclic APIs or complex Gemini surfactants, any trace of unreacted free bromine or moisture in your 1,4-Dibromobutane will catalyze unwanted side reactions, severely reducing your cyclization yields. Yinglang Chemical employs advanced distillation techniques to supply a pristine ≥ 99.0% product with ultra-low APHA color. By purging our heavy-duty steel drums with Nitrogen, we entirely prevent photolytic and oxidative degradation, ensuring your bifunctional alkylating agent delivers flawless reactivity and flawless regioselectivity in your reactors.
Because 1,4-Dibromobutane is exceptionally dense (~1.8 g/cm³) and sensitive to light and oxidation, we utilize heavy-duty packaging for secure ocean transit:
- 250 KG UN-approved Steel Drums, tightly sealed and Nitrogen-purged to prevent light degradation.
- ISO TANKS available for continuous industrial API procurement.
- Transport Classification: Classified as Dangerous Goods (Typically Class 6.1 Toxic or Class 9).
- UN Number: UN 2810 | Packing Group: III
- Handling Precautions: TOXIC AND IRRITANT. Causes severe skin/eye irritation. Operators MUST handle strictly in well-ventilated environments with proper PPE. Store in a cool, dark DG facility to prevent the release of free bromine.
Contact us today for the latest FOB/CIF pricing, detailed COA, and specialized DG shipping estimates for your pharmaceutical or chemical facility.
Request a Bulk Quote Email Sales & Logistics Team
PACKING AND DELIVERY
Packing and delivery
We offer secure and compliant packaging for a wide range of chemical products, from laboratory bottles (100 mL, 250 mL, 500 mL) to customized bulk containers. All shipments follow international hazardous goods standards and include complete documentation such as COA and SDS. With reliable global logistics partners, we ensure safe, fast, and efficient delivery by air, sea, or land according to customer needs.
FAQ
Q1: What documents and certifications do you provide?
A Standard shipment includes COA (Certificate of Analysis) and MSDS (SDS). We also provide ISO 9001 certification and support third-party inspections like SGS or BV upon request.
Q2: Do you provide custom synthesis or formulation services?
A Yes. If you have specific purity requirements or a unique formulation, our R&D team can provide custom synthesis and adjust the stabilizers/inhibitors to meet your technical specifications.
Q3: What are your terms of payment?
A
For Orders ≤ $1,000: 100% in advance.
For Orders > $1,000: 30% T/T in advance, and the balance before shipment or against the copy of B/L. Irrevocable L/C at sight is also acceptable for bulk orders.
Q4: How long is your price valid?
A Chemical prices fluctuate due to the changes in raw material costs and exchange rates. Please contact our sales team for the latest real-time quotation.
Q5: What packaging and shipping ports are available?
A
We normally ship from Qingdao, Shanghai, or Ningbo.
Standard packaging includes 200kg Drums or 1000kg IBC Totes. We ensure strict safety compliance for both general and hazardous chemical cargoes.
Q6: It's my first time importing chemicals — can you help?
A Absolutely. Importing chemicals requires specific documentation. Our experienced logistics team will assist you with the entire process, including handling customs clearance documents and arranging the most suitable shipping method.