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2-Chloronicotinic Acid | Advanced Pyridine Intermediate | CAS 2942-59-8
Overview
2-Chloronicotinic Acid is a highly reactive, white to off-white crystalline powder. Structurally, it is a sophisticated pyridine derivative featuring both a carboxylic acid group and an activated chlorine atom in the ortho position. This dual-functionality makes it an exceptionally versatile building block in advanced organic synthesis. The activated chlorine is highly susceptible to nucleophilic substitution, while the carboxylic group enables robust esterification and amidation, unlocking complex synthetic pathways for blockbuster pharmaceutical APIs and next-generation agrochemicals.
Product Description
2-Chloronicotinic Acid is a highly reactive, white crystalline powder. Structurally, it is a sophisticated pyridine derivative featuring both a carboxylic acid group and an activated chlorine atom in the ortho position. This dual-functionality makes it an exceptionally versatile building block. The activated chlorine is highly susceptible to nucleophilic substitution, while the carboxylic group enables robust esterification, unlocking complex synthetic pathways for blockbuster pharmaceutical APIs and next-generation agrochemicals.
At Shandong Yinglang Chemical Co., Ltd., established in 2011, we supply bulk commercial volumes of Ultra-High Purity 2-Chloronicotinic Acid to multinational pharmaceutical CDMOs and elite agrochemical formulators. Shipped globally as highly cost-effective Non-Dangerous Goods, our product is meticulously refined to eliminate trace heavy metals and moisture, guaranteeing flawless regioselectivity for your most demanding multi-step syntheses.
For complex API synthesis and high-efficiency herbicides, strict control of trace moisture and isomeric impurities is mandatory. Typical specifications:
| Purity (HPLC) | ≥ 99.0% |
|---|---|
| Moisture / Loss on Drying | ≤ 0.5% |
| Melting Point | 176°C - 180°C |
| Residue on Ignition | ≤ 0.1% |
- Pharmaceutical APIs (Anti-inflammatory): Serves as the critical starting material for synthesizing NSAIDs such as Pranoprofen and Niflumic Acid, utilized globally for pain management.
- Agrochemicals (Herbicides): The indispensable precursor for manufacturing sulfonylurea herbicides, most notably Nicosulfuron, a dominant herbicide for maize crops.
- Complex Heterocyclic Synthesis: Used by chemical CROs as a versatile building block to construct complex fused-ring systems in early-stage drug discovery.
- Specialty Dyes: Acts as an intermediate in the synthesis of advanced functional dyes.
In multi-step API synthesis (such as the production of Niflumic Acid), the initial nucleophilic displacement of the ortho-chlorine atom is the critical rate-determining step. Impure feedstocks laden with isomers or moisture will severely degrade reaction yields and generate toxic byproducts. Yinglang Chemical supplies High-Purity 2-Chloronicotinic Acid (≥ 99.0% by HPLC). By rigorously eliminating isomeric impurities and ensuring an active, uncompromised pyridine ring, we guarantee maximum regioselectivity and seamless scale-up reliability in your reactors.
As a stable crystalline powder, we offer cost-effective and highly secure bulk packaging for global ocean transit:
- 25 KG UN-approved Fiber Drums with thick double-layered PE inner liners (Tightly sealed to prevent moisture ingress).
- 25 KG Heavy-duty cartons with PE inner liners.
- Palletized loads available for continuous, large-scale industrial procurement.
Contact us today for the latest FOB/CIF pricing, detailed COA, and Non-DG logistics estimates for your pharmaceutical or agrochemical facility.
Request a Bulk Quote Email Tech & Logistics Team
PACKING AND DELIVERY
Packing and delivery
We offer secure and compliant packaging for a wide range of chemical products, from laboratory bottles (100 mL, 250 mL, 500 mL) to customized bulk containers. All shipments follow international hazardous goods standards and include complete documentation such as COA and SDS. With reliable global logistics partners, we ensure safe, fast, and efficient delivery by air, sea, or land according to customer needs.
FAQ
Q1: What documents and certifications do you provide?
A Standard shipment includes COA (Certificate of Analysis) and MSDS (SDS). We also provide ISO 9001 certification and support third-party inspections like SGS or BV upon request.
Q2: Do you provide custom synthesis or formulation services?
A Yes. If you have specific purity requirements or a unique formulation, our R&D team can provide custom synthesis and adjust the stabilizers/inhibitors to meet your technical specifications.
Q3: What are your terms of payment?
A
For Orders ≤ $1,000: 100% in advance.
For Orders > $1,000: 30% T/T in advance, and the balance before shipment or against the copy of B/L. Irrevocable L/C at sight is also acceptable for bulk orders.
Q4: How long is your price valid?
A Chemical prices fluctuate due to the changes in raw material costs and exchange rates. Please contact our sales team for the latest real-time quotation.
Q5: What packaging and shipping ports are available?
A
We normally ship from Qingdao, Shanghai, or Ningbo.
Standard packaging includes 200kg Drums or 1000kg IBC Totes. We ensure strict safety compliance for both general and hazardous chemical cargoes.
Q6: It's my first time importing chemicals — can you help?
A Absolutely. Importing chemicals requires specific documentation. Our experienced logistics team will assist you with the entire process, including handling customs clearance documents and arranging the most suitable shipping method.