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CAS 00-58-3 Phenylmagnesium bromide
Overview
Phenylmagnesium bromide (PhMgBr; CAS 100-58-3; C₆H₅MgBr) is a versatile aryl Grignard reagent supplied as a moisture-sensitive solution (typically 1.0–2.0 M in diethyl ether or THF) for nucleophilic phenylation and C–C bond construction.
Product Description
CAS 00-58-3 Phenylmagnesium bromide
Appearance is colorless to pale yellow; titration-standardized for active base. Highly air-/moisture-sensitive; reacts violently with water/protic media—handle and transfer strictly under dry inert gas with dry glassware; control additions (−20 °C to reflux, per substrate) and use validated quenches (e.g., i-PrOH then aq. NH₄Cl). Solvents are highly flammable. COA/TDS/SDS available; custom solvent/concentration and lab-to-bulk septum-sealed packaging on request.
Phenylmagnesium Bromide (PhMgBr) — Product Specification
CAS: 100-58-3 | Formula: C6H5MgBr | Type: Aryl Grignard reagent (solution)
Identity & Form
| Product form | Moisture-sensitive solution; colorless to pale-yellow |
|---|---|
| Typical concentrations | 1.0 – 2.0 M (custom on request) |
| Solvent options | Tetrahydrofuran (THF) · Diethyl ether |
| Main functions | Nucleophilic phenylation; additions to carbonyls/epoxides; CO2 carboxylation; Kumada-type couplings |
| Documents | COA · TDS · SDS · DG shipping documents |
Typical Specification — 1.0 M in THF (example)
| Concentration (active base, titration) | 1.00 M ± 0.03 M |
|---|---|
| Total base | ≥ 1.02 M (Gilman double titration) |
| Residual bromobenzene | ≤ 0.20% (GC) |
| Water (Karl Fischer) | ≤ 200 ppm |
| Color (APHA) | ≤ 50 |
| Appearance | Clear, colorless to pale-yellow; free from visible particulates |
Typical Specification — 2.0 M in Diethyl Ether (example)
| Concentration (active base, titration) | 2.00 M ± 0.05 M |
|---|---|
| Total base | ≥ 2.04 M (Gilman double titration) |
| Free magnesium salts (as MgBr2) | ≤ 0.30% (w/w) |
| Water (Karl Fischer) | ≤ 150 ppm |
| Density (20 °C) | Grade-specific; reported on COA |
| Appearance | Clear, colorless to pale-yellow solution |
Applications & Handling
| Main uses | Additions to aldehydes/ketones; epoxide openings; carboxylation; cross-coupling/transmetalation |
|---|---|
| Handling | Extremely air-/moisture-sensitive; reacts violently with water/protic media. Handle strictly under dry inert gas with dry apparatus; avoid oxidants and incompatible halogenated solvents; follow SDS. |
| Storage | Tightly sealed under inert atmosphere at controlled temperature; protect from heat/ignition; flammable solvent. |
Packaging & Logistics
| Lab packs | Septum-sealed glass bottles (e.g., 100 mL · 500 mL · 1 L) |
|---|---|
| Bulk | Inerted, sealed metal containers / returnable cylinders; custom concentration/solvent |
| Shipping | Dangerous Goods (pyrophoric/moisture-reactive tendencies; flammable solvent); compliant packing & labeling |
| Ports | Qingdao · Shanghai · Tianjin |
| To quote (please specify) | Concentration (M), solvent (THF/ether), pack size, destination country/port, and required documents |
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PACKING AND DELIVERY
Packing and delivery
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