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CAS 109-72-8 N-Butyllithium
Overview
n-Butyllithium (n-BuLi, CAS 109-72-8, C₄H₉Li, 64.06 g/mol) is a powerful, small-steric strong base/nucleophile used for kinetic enolate formation, directed lithiation (often with TMEDA), halogen–lithium exchange, C–H metallation/deprotonation, and anionic polymerization of dienes and styrenics. It is typically supplied as 1.6–2.5 M hydrocarbon solutions (e.g., hexanes/isomeric hexanes, heptane, cyclohexane), appearing as a colorless to pale-yellow clear liquid.
Product Description
CAS 109-72-8-N-Butyllithium
n-Butyllithium (n-BuLi, CAS 109-72-8, C₄H₉Li) is a small-steric, super-basic organolithium reagent used for kinetic enolate formation, directed lithiation (often with TMEDA), halogen–lithium exchange, C–H metallation/deprotonation, and anionic polymerization of dienes/styrenics. It delivers fast, clean transformations with high chemo-/regioselectivity at low temperatures (≈ −78–0 °C) under strictly anhydrous conditions.
n-Butyllithium (n-BuLi) — Product Specification
CAS: 109-72-8 | Formula: C4H9Li | Molecular weight: 64.06 g/mol | Synonyms: n-Butyl lithium; n-BuLi
Identity & Form
| Product form | Solution in hydrocarbons; colorless to pale-yellow clear liquid |
|---|---|
| Typical concentrations | 1.6–2.5 M (custom on request) |
| Solvent options | Hexanes / isomeric hexanes · Heptane · Cyclohexane |
| Main functions | Strong base/nucleophile for kinetic enolates, directed lithiation, halogen–lithium exchange, C–H metallation, anionic polymerization |
| Documents | COA · TDS · SDS · DG documents |
Typical Specification — 1.6 M in Hexanes (example)
| Concentration (titration) | 1.60 M ± 0.05 M |
|---|---|
| Active base purity | ≥ 99.0% of titratable base |
| Water (Karl Fischer) | ≤ 0.020% (w/w) (200 ppm) |
| Residual halides (as Cl⁻/Br⁻) | ≤ 200 ppm |
| Color (APHA) | ≤ 50 |
| Appearance | Clear, colorless to pale-yellow; free from visible particulates |
Applications & Handling
| Main uses | Kinetic enolate formation; directed lithiation (often with TMEDA); halogen–lithium exchange; C–H deprotonation; initiation of anionic polymerizations |
|---|---|
| Handling | Extremely air-/moisture-sensitive and pyrophoric. Operate under dry inert gas with grounded, explosion-proof setups; avoid water, alcohols, acids, CO2, and oxidants; use validated quench procedures. |
| Storage | Tightly sealed under inert atmosphere at controlled temperature; keep away from heat/ignition and incompatible materials. |
Packaging & Logistics
| Lab packs | Septum-sealed glass bottles (e.g., 100 mL · 500 mL · 1 L) |
|---|---|
| Bulk | Inerted, sealed metal containers / returnable cylinders; custom concentrations available |
| Shipping | Dangerous Goods (pyrophoric liquid; flammable hydrocarbon solvent); compliant packing & labeling |
| Ports | Qingdao · Shanghai · Tianjin |
| To quote (please specify) | Concentration (M), solvent system, pack size, destination country/port, and required documents |
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PACKING AND DELIVERY
Packing and delivery
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