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Dotinurad | Advanced URAT1 Inhibitor API | CAS 1286770-55-5
Overview
Dotinurad is a novel, highly selective Urate Transporter 1 (URAT1) inhibitor. Appearing as a white to off-white crystalline powder, it represents the next generation of therapeutics for gout and asymptomatic hyperuricemia. Unlike older xanthine oxidase inhibitors that carry cardiovascular warnings, or early-generation uricosuric agents with severe hepatotoxicity, Dotinurad selectively targets uric acid reabsorption in the kidneys. This precision delivers unparalleled serum uric acid reduction with a highly favorable safety profile.
Product Description
Dotinurad is a novel, highly selective Urate Transporter 1 (URAT1) inhibitor. Appearing as a white to off-white crystalline powder, it represents the next generation of therapeutics for gout and asymptomatic hyperuricemia. Unlike older xanthine oxidase inhibitors that carry cardiovascular warnings, or early-generation uricosuric agents with severe hepatotoxicity, Dotinurad selectively targets uric acid reabsorption in the kidneys. This precision delivers unparalleled serum uric acid reduction with a highly favorable safety profile.
At Shandong Yinglang Chemical Co., Ltd., established in 2011, we supply Ultra-High Purity Dotinurad Active Pharmaceutical Ingredient (API) to global pharmaceutical formulators and forward-thinking CROs. Manufactured under stringent quality control systems, our Dotinurad API offers flawlessly controlled crystal polymorphs and strictly minimized related substances, empowering your R&D and commercial production.
For next-generation gout therapeutics, stringent control over single unknown impurities and residual solvents is absolute. Typical specifications:
| Purity (HPLC) | ≥ 99.5% |
|---|---|
| Single Unknown Impurity | ≤ 0.1% |
| Total Impurities | ≤ 0.5% |
| Loss on Drying | ≤ 0.5% |
| Heavy Metals | ≤ 10 ppm |
- Gout & Hyperuricemia Therapeutics: The core API formulated into oral tablets to significantly lower serum uric acid levels, offering a safer alternative to older gout medications with hepatotoxic or cardiovascular risks.
- Bioequivalence & Clinical Trials: Heavily sourced by CROs and generic pharmaceutical manufacturers for bioequivalence (BE) studies and formulation development for global regulatory submissions.
- Pharmacological Research: Utilized in advanced metabolic disease research to study targeted URAT1 inhibition pathways.
The global pharmaceutical market is actively phasing out older uricosuric agents due to off-target toxicity. Dotinurad solves this by exhibiting extreme selectivity for URAT1 without inhibiting other key renal transporters like OAT1 or OAT3, preventing drug-drug interactions and liver damage. Yinglang Chemical’s ≥ 99.5% pure API guarantees that your formulations retain this precise mechanism of action, ensuring a clean safety profile for your clinical trials and commercial product launches.
As a high-value, highly stable pharmaceutical API, we utilize premium barrier packaging to ensure absolute molecular integrity during global air or ocean transit:
- 10 KG / 25 KG UN-approved Fiber Drums with double-layered anti-static PE inner liners for bulk commercial manufacturing.
- 1 KG / 5 KG Triple-layered pharmaceutical-grade aluminum foil bags, vacuum-sealed and protected within insulated carton boxes (Ideal for air freight).
Contact us today for the latest FOB/CIF pricing, detailed COA, and secure air-freight logistics estimates for your pharmaceutical development facility.
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PACKING AND DELIVERY
Packing and delivery
We offer secure and compliant packaging for a wide range of chemical products, from laboratory bottles (100 mL, 250 mL, 500 mL) to customized bulk containers. All shipments follow international hazardous goods standards and include complete documentation such as COA and SDS. With reliable global logistics partners, we ensure safe, fast, and efficient delivery by air, sea, or land according to customer needs.
FAQ
Q1: What documents and certifications do you provide?
A Standard shipment includes COA (Certificate of Analysis) and MSDS (SDS). We also provide ISO 9001 certification and support third-party inspections like SGS or BV upon request.
Q2: Do you provide custom synthesis or formulation services?
A Yes. If you have specific purity requirements or a unique formulation, our R&D team can provide custom synthesis and adjust the stabilizers/inhibitors to meet your technical specifications.
Q3: What are your terms of payment?
A
For Orders ≤ $1,000: 100% in advance.
For Orders > $1,000: 30% T/T in advance, and the balance before shipment or against the copy of B/L. Irrevocable L/C at sight is also acceptable for bulk orders.
Q4: How long is your price valid?
A Chemical prices fluctuate due to the changes in raw material costs and exchange rates. Please contact our sales team for the latest real-time quotation.
Q5: What packaging and shipping ports are available?
A
We normally ship from Qingdao, Shanghai, or Ningbo.
Standard packaging includes 200kg Drums or 1000kg IBC Totes. We ensure strict safety compliance for both general and hazardous chemical cargoes.
Q6: It's my first time importing chemicals — can you help?
A Absolutely. Importing chemicals requires specific documentation. Our experienced logistics team will assist you with the entire process, including handling customs clearance documents and arranging the most suitable shipping method.