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Phenetole | Advanced Pharmaceutical Intermediate | CAS 103-73-1
Overview
Phenetole, widely known as Ethoxybenzene or Ethyl phenyl ether, is a clear, colorless liquid with a highly distinctive, aromatic, and slightly sweet odor profile. As an advanced homologue of Anisole, the ethoxy group in Phenetole provides increased lipophilicity and unique steric properties. This makes it an exceptionally valuable intermediate in electrophilic aromatic substitution reactions, unlocking complex synthetic pathways for high-value pharmaceutical APIs, next-generation agrochemicals, and long-lasting synthetic fragrances.
Product Description
Phenetole, widely known as Ethoxybenzene, is a clear, colorless liquid with a highly distinctive, aromatic odor profile. As an advanced homologue of Anisole, the ethoxy group in Phenetole provides increased lipophilicity and unique steric properties. This makes it an exceptionally valuable intermediate in electrophilic aromatic substitution reactions, unlocking complex synthetic pathways for high-value pharmaceutical APIs, next-generation agrochemicals, and long-lasting synthetic fragrances.
At Shandong Yinglang Chemical Co., Ltd., established in 2011, we supply bulk commercial volumes of Ultra-High Purity Phenetole to multinational pharmaceutical CROs and elite fragrance formulation houses. Operating securely under Class 3 Dangerous Goods protocols, our Phenetole is packaged in tightly sealed, anti-static environments to ensure absolute molecular integrity and zero moisture ingress during global transit.
For sensitive API synthesis and high-end cosmetic formulations, strict control of trace moisture and unreacted phenol impurities is absolute. Typical specifications:
| Purity (Phenetole) | ≥ 99.5% |
|---|---|
| Moisture / Water | ≤ 0.05% |
| Phenol Content | ≤ 0.05% |
| Color (Pt-Co) | ≤ 10 |
| Density (at 20°C) | 0.965 - 0.969 g/cm³ |
- Advanced Pharma APIs: Utilized in the synthesis of complex cardiovascular therapeutics and central nervous system drugs where the ethoxy group significantly enhances drug lipophilicity and bioavailability.
- Premium Fragrances: Highly prized in perfumery for providing a robust, long-lasting sweet-spicy note to luxury soaps and fine fragrances.
- Specialty Agrochemicals: Actively utilized in the synthesis of high-efficiency, broad-spectrum fungicides.
- High-Boiling Solvent: Acts as an exceptionally stable reaction solvent in demanding organic syntheses.
In modern drug design, modifying an active pharmaceutical ingredient (API) with an ethoxy group rather than a methoxy group can drastically improve its lipophilicity (fat-solubility). This enables the drug to more effectively cross cellular membranes and the blood-brain barrier. Yinglang Chemical’s ≥ 99.5% pure Phenetole serves as the perfect high-yield starting material for these advanced syntheses. By rigorously capping unreacted phenol impurities at ≤ 0.05%, we guarantee flawless regioselectivity in your downstream Friedel-Crafts or halogenation reactions.
Because Phenetole is a volatile and flammable liquid, we utilize highly secure, vapor-tight packaging for safe ocean transit:
- 200 KG UN-approved Steel Drums, tightly sealed and Nitrogen-purged to prevent oxidation and moisture contamination.
- ISO TANKS (20 MT) available for continuous, large-scale industrial procurement.
- Transport Classification: Classified as Class 3 (Flammable Liquid).
- UN Number: UN 3271 (Ethers, n.o.s.) | Packing Group: III
- Handling Precautions: FLAMMABLE LIQUID AND VAPOR. Vapor accumulation can form explosive mixtures. Operators MUST handle strictly in well-ventilated, explosion-proof environments with proper grounding. Store in a cool DG facility.
Contact us today for the latest FOB/CIF pricing, detailed COA, and specialized Class 3 DG shipping estimates for your pharmaceutical or fragrance facility.
Request a Bulk Quote Email Sales & Logistics Team
PACKING AND DELIVERY
Packing and delivery
We offer secure and compliant packaging for a wide range of chemical products, from laboratory bottles (100 mL, 250 mL, 500 mL) to customized bulk containers. All shipments follow international hazardous goods standards and include complete documentation such as COA and SDS. With reliable global logistics partners, we ensure safe, fast, and efficient delivery by air, sea, or land according to customer needs.
FAQ
Q1: What documents and certifications do you provide?
A Standard shipment includes COA (Certificate of Analysis) and MSDS (SDS). We also provide ISO 9001 certification and support third-party inspections like SGS or BV upon request.
Q2: Do you provide custom synthesis or formulation services?
A Yes. If you have specific purity requirements or a unique formulation, our R&D team can provide custom synthesis and adjust the stabilizers/inhibitors to meet your technical specifications.
Q3: What are your terms of payment?
A
For Orders ≤ $1,000: 100% in advance.
For Orders > $1,000: 30% T/T in advance, and the balance before shipment or against the copy of B/L. Irrevocable L/C at sight is also acceptable for bulk orders.
Q4: How long is your price valid?
A Chemical prices fluctuate due to the changes in raw material costs and exchange rates. Please contact our sales team for the latest real-time quotation.
Q5: What packaging and shipping ports are available?
A
We normally ship from Qingdao, Shanghai, or Ningbo.
Standard packaging includes 200kg Drums or 1000kg IBC Totes. We ensure strict safety compliance for both general and hazardous chemical cargoes.
Q6: It's my first time importing chemicals — can you help?
A Absolutely. Importing chemicals requires specific documentation. Our experienced logistics team will assist you with the entire process, including handling customs clearance documents and arranging the most suitable shipping method.